Drug interactions
Deflazacort + Tolmetin
Severity: Moderate
Deflazacort and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs increase the likelihood of peptic ulceration and gastrointestinal bleeding. The risk is greater with higher steroid doses, longer treatment and in older patients.
What this interaction means in plain words
Deflazacort and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive gastric mucosal injury from NSAID suppression of protective prostaglandins and corticosteroid impairment of mucosal healing.
What to do
Use the shortest possible duration of both agents and consider a proton pump inhibitor. Monitor for dyspepsia, melena and anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Tolmetin?
MediHelp rates the interaction as moderate. Deflazacort and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs increase the likelihood of peptic ulceration and gastrointestinal bleeding. The risk is greater with higher steroid doses, longer treatment and in older patients.
How serious is the interaction between Deflazacort and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest possible duration of both agents and consider a proton pump inhibitor. Monitor for dyspepsia, melena and anemia.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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