Drug interactions
Deflazacort + Trastuzumab
Severity: Moderate
Deflazacort and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab combined with corticosteroids and myelosuppressive therapy may increase the risk of neutropenia and infection. Corticosteroid immunosuppression adds to this risk.
What this interaction means in plain words
Deflazacort and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Trastuzumab belongs to Oncology.
Why it happens
Additive immunosuppressive effects of corticosteroid and trastuzumab-associated neutropenia in combination with chemotherapy.
What to do
Monitor blood counts and signs of infection, and use the lowest effective corticosteroid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Deflazacort with Trastuzumab?
MediHelp rates the interaction as moderate. Deflazacort and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab combined with corticosteroids and myelosuppressive therapy may increase the risk of neutropenia and infection. Corticosteroid immunosuppression adds to this risk.
How serious is the interaction between Deflazacort and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of infection, and use the lowest effective corticosteroid dose.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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