Drug interactions
Degarelix + Fingolimod
Severity: Moderate
Degarelix and Fingolimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Degarelix and other androgen deprivation therapy can prolong the QT interval, and fingolimod can cause bradycardia and QT effects. Together they may raise the risk of ventricular arrhythmia, especially in patients with cardiac risk factors.
What this interaction means in plain words
Degarelix and Fingolimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Fingolimod belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with fingolimod-related bradycardia increasing risk.
What to do
Check a baseline ECG and electrolytes and monitor ECG after fingolimod initiation; avoid in patients with congenital long QT or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Fingolimod?
MediHelp rates the interaction as moderate. Degarelix and Fingolimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Degarelix and other androgen deprivation therapy can prolong the QT interval, and fingolimod can cause bradycardia and QT effects. Together they may raise the risk of ventricular arrhythmia, especially in patients with cardiac risk factors.
How serious is the interaction between Degarelix and Fingolimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and monitor ECG after fingolimod initiation; avoid in patients with congenital long QT or other QT-prolonging drugs.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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