Drug interactions
Degarelix + Imipramine
Severity: Moderate
Degarelix and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with degarelix can prolong the QT interval, and imipramine has its own effect on cardiac repolarization and conduction. Together they may increase the risk of torsades de pointes, particularly with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Degarelix and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Imipramine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation through pharmacodynamic effects.
What to do
Obtain a baseline ECG and correct potassium and magnesium before and during therapy. Monitor the QTc periodically, and reassess the combination if the interval lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Imipramine?
MediHelp rates the interaction as moderate. Degarelix and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with degarelix can prolong the QT interval, and imipramine has its own effect on cardiac repolarization and conduction. Together they may increase the risk of torsades de pointes, particularly with electrolyte disturbances or cardiac disease.
How serious is the interaction between Degarelix and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before and during therapy. Monitor the QTc periodically, and reassess the combination if the interval lengthens significantly.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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