Drug interactions
Degarelix + Nortriptyline
Severity: Moderate
Degarelix and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Androgen deprivation therapy with degarelix may lengthen QT, and nortriptyline adds to this effect, raising the risk of torsades de pointes, especially with electrolyte disturbance or heart disease.
What this interaction means in plain words
Degarelix and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive QT prolongation through pharmacodynamic effects on cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG after starting and consider an alternative antidepressant in patients with existing QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Nortriptyline?
MediHelp rates the interaction as moderate. Degarelix and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval. Androgen deprivation therapy with degarelix may lengthen QT, and nortriptyline adds to this effect, raising the risk of torsades de pointes, especially with electrolyte disturbance or heart disease.
How serious is the interaction between Degarelix and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG after starting and consider an alternative antidepressant in patients with existing QT risk factors.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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