Drug interactions
Degarelix + Ofloxacin
Severity: Moderate
Degarelix and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with degarelix can prolong the QT interval, and ofloxacin may add to that effect. The combination can increase proarrhythmic risk in older men with cardiac comorbidity.
What this interaction means in plain words
Degarelix and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, with androgen suppression altering cardiac repolarization.
What to do
Evaluate QT risk factors and consider a non-quinolone antibiotic. Obtain an ECG and check electrolytes if the combination cannot be avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Ofloxacin?
MediHelp rates the interaction as moderate. Degarelix and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with degarelix can prolong the QT interval, and ofloxacin may add to that effect. The combination can increase proarrhythmic risk in older men with cardiac comorbidity.
How serious is the interaction between Degarelix and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Evaluate QT risk factors and consider a non-quinolone antibiotic. Obtain an ECG and check electrolytes if the combination cannot be avoided.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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