Drug interactions
Degarelix + Quinine
Severity: Moderate
Degarelix and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with degarelix may prolong the QT interval, and quinine can add to this effect. The combined risk of arrhythmia is greater in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Degarelix and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Quinine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and electrolytes, and monitor the QTc if quinine is needed during degarelix therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Quinine?
MediHelp rates the interaction as moderate. Degarelix and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with degarelix may prolong the QT interval, and quinine can add to this effect. The combined risk of arrhythmia is greater in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Degarelix and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes, and monitor the QTc if quinine is needed during degarelix therapy.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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