Drug interactions
Degarelix + Salbutamol
Severity: Moderate
Degarelix and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with degarelix may prolong the QT interval, and salbutamol may add to this effect and cause hypokalemia at higher doses. The combination may increase arrhythmia risk in patients with cardiac disease or electrolyte disturbance.
What this interaction means in plain words
Degarelix and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia contributing.
What to do
Monitor ECG and electrolytes in patients with cardiac risk factors who need regular or high-dose salbutamol while on degarelix. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Salbutamol?
MediHelp rates the interaction as moderate. Degarelix and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with degarelix may prolong the QT interval, and salbutamol may add to this effect and cause hypokalemia at higher doses. The combination may increase arrhythmia risk in patients with cardiac disease or electrolyte disturbance.
How serious is the interaction between Degarelix and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with cardiac risk factors who need regular or high-dose salbutamol while on degarelix. Correct potassium and magnesium abnormalities.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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