Drug interactions
Delandistrogene moxeparvovec + Pneumococcal vaccine 13-valent
Severity: Minor
Delandistrogene moxeparvovec and Pneumococcal vaccine 13-valent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Delandistrogene moxeparvovec is given with a corticosteroid regimen, and high-dose or prolonged corticosteroids can reduce the immune response to vaccines. Pneumococcal vaccination around this time may therefore be less effective.
What this interaction means in plain words
Delandistrogene moxeparvovec and Pneumococcal vaccine 13-valent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Corticosteroids given with the gene therapy suppress immune responses, which may reduce vaccine immunogenicity.
What to do
Check immunization status before starting the steroid regimen and complete the pneumococcal vaccine, ideally at least 4 weeks before starting steroids. Review the response or revaccinate as clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Frequently asked questions
Can I take Delandistrogene moxeparvovec with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as minor. Delandistrogene moxeparvovec and Pneumococcal vaccine 13-valent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Delandistrogene moxeparvovec is given with a corticosteroid regimen, and high-dose or prolonged corticosteroids can reduce the immune response to vaccines. Pneumococcal vaccination around this time may therefore be less effective.
How serious is the interaction between Delandistrogene moxeparvovec and Pneumococcal vaccine 13-valent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check immunization status before starting the steroid regimen and complete the pneumococcal vaccine, ideally at least 4 weeks before starting steroids. Review the response or revaccinate as clinically indicated.
What other medicines interact with Pneumococcal vaccine 13-valent?
MediHelp also lists interactions of Pneumococcal vaccine 13-valent with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Pneumococcal vaccine 13-valent page.
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