Drug interactions
Delavirdine + Warfarin
Severity: Moderate
Delavirdine and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Delavirdine inhibits several CYP enzymes and may raise warfarin exposure, increasing INR and bleeding risk.
What this interaction means in plain words
Delavirdine and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Delavirdine inhibits CYP3A4, CYP2C9 and CYP2C19, reducing warfarin metabolism.
What to do
Monitor INR more often when starting or stopping delavirdine and lower the warfarin dose if INR rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Delavirdine with Warfarin?
MediHelp rates the interaction as moderate. Delavirdine and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Delavirdine inhibits several CYP enzymes and may raise warfarin exposure, increasing INR and bleeding risk.
How serious is the interaction between Delavirdine and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more often when starting or stopping delavirdine and lower the warfarin dose if INR rises.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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