Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Methoxsalen
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is photosensitizing and may add to the phototoxic effects of methoxsalen with UV exposure, increasing the risk of burns.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive photosensitizing effects of both agents.
What to do
Counsel on strict UV protection and monitor skin response during PUVA therapy, adjusting UV dose if exaggerated reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Methoxsalen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Methoxsalen?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide is photosensitizing and may add to the phototoxic effects of methoxsalen with UV exposure, increasing the risk of burns.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on strict UV protection and monitor skin response during PUVA therapy, adjusting UV dose if exaggerated reactions occur.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
