Drug interactions
Demeclocycline + Warfarin
Severity: Moderate
Demeclocycline and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracyclines can increase the anticoagulant effect of warfarin, with raised INR and possible bleeding.
What this interaction means in plain words
Demeclocycline and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Likely reduction of gut bacterial vitamin K synthesis; the mechanism is not firmly established.
What to do
Monitor INR during and after a demeclocycline course and reduce the warfarin dose if INR rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Demeclocycline with Warfarin?
MediHelp rates the interaction as moderate. Demeclocycline and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetracyclines can increase the anticoagulant effect of warfarin, with raised INR and possible bleeding.
How serious is the interaction between Demeclocycline and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR during and after a demeclocycline course and reduce the warfarin dose if INR rises.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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