Drug interactions
Dengue vaccine + Guselkumab
Severity: Moderate
Dengue vaccine and Guselkumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine, and immunomodulating therapy may impair the vaccine response or raise safety concerns. Guselkumab's effect on immune response to this vaccine has not been well characterized.
What this interaction means in plain words
Dengue vaccine and Guselkumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunomodulation through IL-23 inhibition may alter the response to a live attenuated vaccine.
What to do
Avoid live vaccines during guselkumab therapy where possible and complete vaccination before starting treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Frequently asked questions
Can I take Dengue vaccine with Guselkumab?
MediHelp rates the interaction as moderate. Dengue vaccine and Guselkumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dengue vaccine is a live attenuated vaccine, and immunomodulating therapy may impair the vaccine response or raise safety concerns. Guselkumab's effect on immune response to this vaccine has not been well characterized.
How serious is the interaction between Dengue vaccine and Guselkumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during guselkumab therapy where possible and complete vaccination before starting treatment.
What other medicines interact with Guselkumab?
MediHelp also lists interactions of Guselkumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Guselkumab page.
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