Drug interactions
Dengue vaccine + Lapatinib
Severity: Moderate
Dengue vaccine and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine. Lapatinib is a targeted kinase inhibitor, not a classic immunosuppressant, and a clear effect on vaccine response has not been established, although patients with active cancer may have impaired immunity.
What this interaction means in plain words
Dengue vaccine and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible reduced immune response or vaccine safety concerns in an immunocompromised patient; not clearly established for lapatinib.
What to do
Avoid live vaccines during anticancer therapy unless the oncology team judges the benefit to outweigh risk. Consider timing vaccination before therapy begins.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dengue vaccine and Lapatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Dengue vaccine with Lapatinib?
MediHelp rates the interaction as moderate. Dengue vaccine and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dengue vaccine is a live attenuated vaccine. Lapatinib is a targeted kinase inhibitor, not a classic immunosuppressant, and a clear effect on vaccine response has not been established, although patients with active cancer may have impaired immunity.
How serious is the interaction between Dengue vaccine and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during anticancer therapy unless the oncology team judges the benefit to outweigh risk. Consider timing vaccination before therapy begins.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
