Drug interactions
Dengue vaccine + Obinutuzumab
Severity: Major
Dengue vaccine and Obinutuzumab: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine, and obinutuzumab-induced B-cell depletion may weaken the immune response and permit vaccine strain replication. This leaves the patient potentially unprotected and at some risk of vaccine-related infection.
What this interaction means in plain words
Dengue vaccine and Obinutuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
B-cell depletion by obinutuzumab suppresses humoral immunity, impairing vaccine response and control of live attenuated virus.
What to do
Avoid giving the dengue vaccine during obinutuzumab treatment and until B-cell recovery. If vaccination is needed, schedule it before therapy where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Obinutuzumab
Frequently asked questions
Can I take Dengue vaccine with Obinutuzumab?
MediHelp rates the interaction as major. Dengue vaccine and Obinutuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is a live attenuated vaccine, and obinutuzumab-induced B-cell depletion may weaken the immune response and permit vaccine strain replication. This leaves the patient potentially unprotected and at some risk of vaccine-related infection.
How serious is the interaction between Dengue vaccine and Obinutuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the dengue vaccine during obinutuzumab treatment and until B-cell recovery. If vaccination is needed, schedule it before therapy where possible.
What other medicines interact with Obinutuzumab?
MediHelp also lists interactions of Obinutuzumab with, for example, Measles mumps and rubella vaccine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Obinutuzumab page.
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