Drug interactions
Dengue vaccine + Prednisone
Severity: Major
Dengue vaccine and Prednisone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressive doses of prednisone may blunt the immune response to the live attenuated dengue vaccine and raise the risk of vaccine-related infection. Protection may be inadequate if given during therapy.
What this interaction means in plain words
Dengue vaccine and Prednisone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Corticosteroid-induced immunosuppression reduces vaccine immunogenicity and may permit replication of the live vaccine virus.
What to do
Avoid the live vaccine in patients on immunosuppressive steroid doses and vaccinate before therapy or after steroids are stopped, per product labeling. Reassess immunity if vaccinated during steroid use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Dengue vaccine with Prednisone?
MediHelp rates the interaction as major. Dengue vaccine and Prednisone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Immunosuppressive doses of prednisone may blunt the immune response to the live attenuated dengue vaccine and raise the risk of vaccine-related infection. Protection may be inadequate if given during therapy.
How serious is the interaction between Dengue vaccine and Prednisone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live vaccine in patients on immunosuppressive steroid doses and vaccinate before therapy or after steroids are stopped, per product labeling. Reassess immunity if vaccinated during steroid use.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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