Drug interactions
Dengue vaccine + Sarilumab
Severity: Major
Dengue vaccine and Sarilumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine. Sarilumab is immunosuppressive and may blunt vaccine response and increase the risk of vaccine-related infection.
What this interaction means in plain words
Dengue vaccine and Sarilumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Immunosuppression from IL-6 receptor blockade reduces vaccine response and may permit replication of the live virus.
What to do
Avoid live vaccines during sarilumab therapy; vaccinate before starting treatment where possible, allowing the usual interval before immunosuppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sarilumab
Frequently asked questions
Can I take Dengue vaccine with Sarilumab?
MediHelp rates the interaction as major. Dengue vaccine and Sarilumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is a live attenuated vaccine. Sarilumab is immunosuppressive and may blunt vaccine response and increase the risk of vaccine-related infection.
How serious is the interaction between Dengue vaccine and Sarilumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during sarilumab therapy; vaccinate before starting treatment where possible, allowing the usual interval before immunosuppression.
What other medicines interact with Sarilumab?
MediHelp also lists interactions of Sarilumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Measles mumps and rubella vaccine. The full list is on the Sarilumab page.
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