Drug interactions
Measles mumps and rubella vaccine + Sarilumab
Severity: Major
Measles mumps and rubella vaccine and Sarilumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarilumab is an IL-6 receptor antagonist that suppresses immune function. Live vaccines may increase infection risk and response may be reduced.
What this interaction means in plain words
Measles mumps and rubella vaccine and Sarilumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Measles mumps and rubella vaccine belongs to Miscellaneous; Sarilumab belongs to Musculoskeletal.
Why it happens
IL-6 receptor blockade causes immunosuppression and impaired control of live attenuated virus.
What to do
Avoid live vaccines during sarilumab therapy; complete them before starting following guideline intervals.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Sarilumab
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Sarilumab?
MediHelp rates the interaction as major. Measles mumps and rubella vaccine and Sarilumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sarilumab is an IL-6 receptor antagonist that suppresses immune function. Live vaccines may increase infection risk and response may be reduced.
How serious is the interaction between Measles mumps and rubella vaccine and Sarilumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during sarilumab therapy; complete them before starting following guideline intervals.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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