Drug interactions
Measles mumps rubella and varicella vaccine live + Sarilumab
Severity: Major
Measles mumps rubella and varicella vaccine live and Sarilumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This vaccine contains live attenuated viruses, and sarilumab-induced immunosuppression may allow vaccine-strain infection to spread. The vaccine response may also be impaired.
What this interaction means in plain words
Measles mumps rubella and varicella vaccine live and Sarilumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
IL-6 receptor blockade suppresses immunity, potentially permitting uncontrolled replication of live attenuated virus.
What to do
Avoid during sarilumab therapy. Give the vaccine at least several weeks before starting sarilumab, following current immunization guidelines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sarilumab
Frequently asked questions
Can I take Measles mumps rubella and varicella vaccine live with Sarilumab?
MediHelp rates the interaction as major. Measles mumps rubella and varicella vaccine live and Sarilumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. This vaccine contains live attenuated viruses, and sarilumab-induced immunosuppression may allow vaccine-strain infection to spread. The vaccine response may also be impaired.
How serious is the interaction between Measles mumps rubella and varicella vaccine live and Sarilumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during sarilumab therapy. Give the vaccine at least several weeks before starting sarilumab, following current immunization guidelines.
What other medicines interact with Sarilumab?
MediHelp also lists interactions of Sarilumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Dengue vaccine. The full list is on the Sarilumab page.
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