Drug interactions
Desipramine + Dexfenfluramine
Severity: Moderate
Desipramine and Dexfenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine is a serotonergic agent that has been withdrawn from the market in most countries. Combination with a tricyclic antidepressant could contribute to serotonergic toxicity, but available data are limited.
What this interaction means in plain words
Desipramine and Dexfenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects are theoretical; the sympathomimetic reuptake interaction is not well established for this drug.
What to do
Avoid concurrent use. If a patient is exposed, monitor for serotonin toxicity such as agitation, tremor, hyperthermia and hyperreflexia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Dexfenfluramine?
MediHelp rates the interaction as moderate. Desipramine and Dexfenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexfenfluramine is a serotonergic agent that has been withdrawn from the market in most countries. Combination with a tricyclic antidepressant could contribute to serotonergic toxicity, but available data are limited.
How serious is the interaction between Desipramine and Dexfenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If a patient is exposed, monitor for serotonin toxicity such as agitation, tremor, hyperthermia and hyperreflexia.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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