Drug interactions
Desipramine + Dextromoramide
Severity: Moderate
Desipramine and Dextromoramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a potent opioid with a tricyclic antidepressant adds to sedation and may increase respiratory depression and hypotension. The risk is greater in elderly or frail patients and at higher opioid doses.
What this interaction means in plain words
Desipramine and Dextromoramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression.
What to do
Use the lowest effective opioid dose and monitor sedation and respiratory rate. Counsel the patient about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Dextromoramide?
MediHelp rates the interaction as moderate. Desipramine and Dextromoramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a potent opioid with a tricyclic antidepressant adds to sedation and may increase respiratory depression and hypotension. The risk is greater in elderly or frail patients and at higher opioid doses.
How serious is the interaction between Desipramine and Dextromoramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor sedation and respiratory rate. Counsel the patient about driving and alcohol.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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