Drug interactions
Desipramine + Diazepam intranasal
Severity: Moderate
Desipramine and Diazepam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can deepen sedation, impair psychomotor performance and slow reaction time. The risk is greatest in older adults and when doses are being increased.
What this interaction means in plain words
Desipramine and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic CNS depression from GABA-A potentiation by diazepam and sedating antihistaminic and anticholinergic effects of desipramine.
What to do
Use the lowest effective doses and counsel patients to avoid driving or hazardous tasks until response is known. Monitor for excessive sedation and reduce the dose of either drug if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Diazepam intranasal?
MediHelp rates the interaction as moderate. Desipramine and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can deepen sedation, impair psychomotor performance and slow reaction time. The risk is greatest in older adults and when doses are being increased.
How serious is the interaction between Desipramine and Diazepam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients to avoid driving or hazardous tasks until response is known. Monitor for excessive sedation and reduce the dose of either drug if it occurs.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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