Drug interactions
Desipramine + Diethylpropion
Severity: Moderate
Desipramine and Diethylpropion: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic stimulant that acts partly by releasing norepinephrine. Tricyclic antidepressants may alter its effect and add to cardiovascular stimulation, leading to hypertension, tachycardia or arrhythmia.
What this interaction means in plain words
Desipramine and Diethylpropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclics block norepinephrine reuptake and uptake of indirect sympathomimetics, altering the pressor and stimulant response.
What to do
Avoid if a safer weight-loss approach exists. If used together, monitor blood pressure and heart rate, particularly early in therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Diethylpropion?
MediHelp rates the interaction as moderate. Desipramine and Diethylpropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diethylpropion is a sympathomimetic stimulant that acts partly by releasing norepinephrine. Tricyclic antidepressants may alter its effect and add to cardiovascular stimulation, leading to hypertension, tachycardia or arrhythmia.
How serious is the interaction between Desipramine and Diethylpropion?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if a safer weight-loss approach exists. If used together, monitor blood pressure and heart rate, particularly early in therapy.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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