Drug interactions
Desipramine + Dopexamine
Severity: Moderate
Desipramine and Dopexamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopexamine is a catecholamine that is also a norepinephrine uptake inhibitor, and tricyclics block norepinephrine reuptake. Combined use may potentiate cardiovascular effects such as tachycardia, hypertension and arrhythmia.
What this interaction means in plain words
Desipramine and Dopexamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of norepinephrine reuptake and enhanced adrenergic response.
What to do
Monitor blood pressure, heart rate and ECG continuously during dopexamine infusion in patients taking desipramine. Titrate the dose carefully.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Dopexamine?
MediHelp rates the interaction as moderate. Desipramine and Dopexamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dopexamine is a catecholamine that is also a norepinephrine uptake inhibitor, and tricyclics block norepinephrine reuptake. Combined use may potentiate cardiovascular effects such as tachycardia, hypertension and arrhythmia.
How serious is the interaction between Desipramine and Dopexamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG continuously during dopexamine infusion in patients taking desipramine. Titrate the dose carefully.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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