Drug interactions
Desipramine + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Moderate
Desipramine and Elvitegravir / cobicistat / emtricitabine / tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP2D6, the main enzyme clearing desipramine, so desipramine concentrations may rise. This increases the risk of anticholinergic effects, sedation, hypotension and cardiac conduction effects.
What this interaction means in plain words
Desipramine and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibition of CYP2D6-mediated metabolism of desipramine.
What to do
Consider a lower desipramine dose and titrate to response, checking plasma levels and ECG where available. Monitor for tricyclic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as moderate. Desipramine and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP2D6, the main enzyme clearing desipramine, so desipramine concentrations may rise. This increases the risk of anticholinergic effects, sedation, hypotension and cardiac conduction effects.
How serious is the interaction between Desipramine and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower desipramine dose and titrate to response, checking plasma levels and ECG where available. Monitor for tricyclic toxicity.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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