Drug interactions
Desipramine + Epinephrine inhaled
Severity: Moderate
Desipramine and Epinephrine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants block norepinephrine reuptake and can enhance the cardiovascular response to sympathomimetics such as epinephrine. Hypertension, tachycardia and arrhythmias are possible, although systemic exposure from inhaled epinephrine is limited.
What this interaction means in plain words
Desipramine and Epinephrine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of neuronal catecholamine reuptake by desipramine enhances adrenergic receptor stimulation by epinephrine.
What to do
Use inhaled epinephrine at the lowest effective dose and monitor heart rate, blood pressure and rhythm. Be especially careful in patients with cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Epinephrine inhaled?
MediHelp rates the interaction as moderate. Desipramine and Epinephrine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants block norepinephrine reuptake and can enhance the cardiovascular response to sympathomimetics such as epinephrine. Hypertension, tachycardia and arrhythmias are possible, although systemic exposure from inhaled epinephrine is limited.
How serious is the interaction between Desipramine and Epinephrine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use inhaled epinephrine at the lowest effective dose and monitor heart rate, blood pressure and rhythm. Be especially careful in patients with cardiovascular disease.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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