Drug interactions
Desipramine + Esketamine intranasal
Severity: Moderate
Desipramine and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and dissociation, and esketamine can raise blood pressure. Together they may increase drowsiness and impair performance, and the blood pressure effect may add to tricyclic cardiovascular effects.
What this interaction means in plain words
Desipramine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive sympathomimetic and cardiovascular effects.
What to do
Monitor sedation and blood pressure during and after esketamine dosing. Advise against driving until the next day after a restful sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Esketamine intranasal?
MediHelp rates the interaction as moderate. Desipramine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and dissociation, and esketamine can raise blood pressure. Together they may increase drowsiness and impair performance, and the blood pressure effect may add to tricyclic cardiovascular effects.
How serious is the interaction between Desipramine and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during and after esketamine dosing. Advise against driving until the next day after a restful sleep.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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