Drug interactions
Desipramine + Esketamine
Severity: Moderate
Desipramine and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine is a tricyclic antidepressant that is less sedating than most but can still cause drowsiness. With esketamine, sedation may increase, and both can affect heart rate and blood pressure.
What this interaction means in plain words
Desipramine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS effects, with overlapping sympathomimetic cardiovascular effects.
What to do
Monitor blood pressure and sedation before and after esketamine dosing. Counsel the patient on impaired driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Esketamine?
MediHelp rates the interaction as moderate. Desipramine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine is a tricyclic antidepressant that is less sedating than most but can still cause drowsiness. With esketamine, sedation may increase, and both can affect heart rate and blood pressure.
How serious is the interaction between Desipramine and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation before and after esketamine dosing. Counsel the patient on impaired driving.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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