Drug interactions
Desipramine + Estrogens esterified
Severity: Minor
Desipramine and Estrogens esterified: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may reduce the hepatic clearance of tricyclic antidepressants, potentially increasing adverse effects. Clinically important interactions are uncommon.
What this interaction means in plain words
Desipramine and Estrogens esterified have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of hepatic metabolism of tricyclics by estrogens.
What to do
No routine change is needed. Monitor for anticholinergic and cardiovascular adverse effects and adjust desipramine dose if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Estrogens esterified?
MediHelp rates the interaction as minor. Desipramine and Estrogens esterified have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may reduce the hepatic clearance of tricyclic antidepressants, potentially increasing adverse effects. Clinically important interactions are uncommon.
How serious is the interaction between Desipramine and Estrogens esterified?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for anticholinergic and cardiovascular adverse effects and adjust desipramine dose if they appear.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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