Drug interactions
Desipramine + Estropipate
Severity: Minor
Desipramine and Estropipate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may raise tricyclic antidepressant concentrations and adverse effects, and may blunt antidepressant response. The interaction is poorly documented and seldom important.
What this interaction means in plain words
Desipramine and Estropipate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of tricyclic hepatic metabolism by estrogens; mechanism not established.
What to do
Monitor antidepressant response and tolerability when estropipate is started or stopped, and adjust the desipramine dose if necessary.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Estropipate?
MediHelp rates the interaction as minor. Desipramine and Estropipate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may raise tricyclic antidepressant concentrations and adverse effects, and may blunt antidepressant response. The interaction is poorly documented and seldom important.
How serious is the interaction between Desipramine and Estropipate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and tolerability when estropipate is started or stopped, and adjust the desipramine dose if necessary.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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