Drug interactions
Desipramine + Glycopyrrolate inhaled
Severity: Minor
Desipramine and Glycopyrrolate inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled glycopyrrolate has low systemic exposure, but some is absorbed and can add to the antimuscarinic effects of desipramine, including dry mouth, urinary retention and constipation.
What this interaction means in plain words
Desipramine and Glycopyrrolate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antimuscarinic effects, limited by low systemic absorption of the inhaled drug.
What to do
Ask about urinary retention, constipation and dry mouth, particularly in patients with prostatic hypertrophy or narrow-angle glaucoma. No dose change is needed unless symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Glycopyrrolate inhaled?
MediHelp rates the interaction as minor. Desipramine and Glycopyrrolate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Inhaled glycopyrrolate has low systemic exposure, but some is absorbed and can add to the antimuscarinic effects of desipramine, including dry mouth, urinary retention and constipation.
How serious is the interaction between Desipramine and Glycopyrrolate inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about urinary retention, constipation and dry mouth, particularly in patients with prostatic hypertrophy or narrow-angle glaucoma. No dose change is needed unless symptoms arise.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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