Drug interactions
Desipramine + Glycopyrronium tosylate
Severity: Moderate
Desipramine and Glycopyrronium tosylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical glycopyrronium tosylate is applied for axillary hyperhidrosis and has some systemic absorption. With desipramine, additive anticholinergic effects such as dry mouth, blurred vision, urinary retention and constipation may occur.
What this interaction means in plain words
Desipramine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic adverse effects and stop the topical agent if urinary retention, severe constipation or visual changes develop. Take extra care in patients with glaucoma or prostatic hypertrophy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Glycopyrronium tosylate?
MediHelp rates the interaction as moderate. Desipramine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topical glycopyrronium tosylate is applied for axillary hyperhidrosis and has some systemic absorption. With desipramine, additive anticholinergic effects such as dry mouth, blurred vision, urinary retention and constipation may occur.
How serious is the interaction between Desipramine and Glycopyrronium tosylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and stop the topical agent if urinary retention, severe constipation or visual changes develop. Take extra care in patients with glaucoma or prostatic hypertrophy.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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