Drug interactions
Desipramine + Henbane
Severity: Moderate
Desipramine and Henbane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains the antimuscarinic alkaloids hyoscyamine and scopolamine, which add to the anticholinergic burden of desipramine. This can cause confusion, dry mouth, urinary retention, constipation and tachycardia.
What this interaction means in plain words
Desipramine and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects from tropane alkaloids and the tricyclic antidepressant.
What to do
Avoid using henbane products with desipramine where possible. If used, monitor for anticholinergic toxicity, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Henbane?
MediHelp rates the interaction as moderate. Desipramine and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains the antimuscarinic alkaloids hyoscyamine and scopolamine, which add to the anticholinergic burden of desipramine. This can cause confusion, dry mouth, urinary retention, constipation and tachycardia.
How serious is the interaction between Desipramine and Henbane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using henbane products with desipramine where possible. If used, monitor for anticholinergic toxicity, especially in older adults.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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