Drug interactions
Desipramine + Hyoscyamine spray
Severity: Moderate
Desipramine and Hyoscyamine spray: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine oral spray is absorbed systemically and adds antimuscarinic effects to those of desipramine. Dry mouth, constipation, urinary retention, tachycardia and confusion can be more pronounced.
What this interaction means in plain words
Desipramine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic toxicity and use the lowest effective hyoscyamine dose. Consider an alternative in older patients or those with glaucoma or urinary obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Hyoscyamine spray?
MediHelp rates the interaction as moderate. Desipramine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine oral spray is absorbed systemically and adds antimuscarinic effects to those of desipramine. Dry mouth, constipation, urinary retention, tachycardia and confusion can be more pronounced.
How serious is the interaction between Desipramine and Hyoscyamine spray?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and use the lowest effective hyoscyamine dose. Consider an alternative in older patients or those with glaucoma or urinary obstruction.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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