Drug interactions
Desipramine + Icosapent
Severity: Minor
Desipramine and Icosapent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icosapent, a purified omega-3 fatty acid, may modestly prolong bleeding time. Desipramine has weak effects on platelet function through serotonin reuptake inhibition, so the combined effect on bleeding is small and clinically uncommon.
What this interaction means in plain words
Desipramine and Icosapent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive, weak antiplatelet effects (omega-3 fatty acid effect on platelet function and reduced platelet serotonin uptake with desipramine).
What to do
No routine change is needed. Be aware of bleeding in patients who also take anticoagulants or antiplatelet drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Icosapent?
MediHelp rates the interaction as minor. Desipramine and Icosapent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icosapent, a purified omega-3 fatty acid, may modestly prolong bleeding time. Desipramine has weak effects on platelet function through serotonin reuptake inhibition, so the combined effect on bleeding is small and clinically uncommon.
How serious is the interaction between Desipramine and Icosapent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Be aware of bleeding in patients who also take anticoagulants or antiplatelet drugs.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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