Drug interactions
Desipramine + Loxapine inhaled
Severity: Moderate
Desipramine and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine causes sedation and can cause bronchospasm, and desipramine adds CNS depression and anticholinergic effects. Loxapine can also affect the QTc interval and cause hypotension, so the combination warrants attention.
What this interaction means in plain words
Desipramine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant, anticholinergic and hypotensive effects.
What to do
Monitor for excessive sedation, hypotension and respiratory symptoms after each dose. Administer inhaled loxapine only where staff can manage bronchospasm.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Loxapine inhaled?
MediHelp rates the interaction as moderate. Desipramine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine causes sedation and can cause bronchospasm, and desipramine adds CNS depression and anticholinergic effects. Loxapine can also affect the QTc interval and cause hypotension, so the combination warrants attention.
How serious is the interaction between Desipramine and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, hypotension and respiratory symptoms after each dose. Administer inhaled loxapine only where staff can manage bronchospasm.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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