Drug interactions
Desipramine + Lsd
Severity: Moderate
Desipramine and Lsd: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD acts as a serotonin receptor agonist, and tricyclic antidepressants such as desipramine may change the intensity of its effects. Combined use may produce unpredictable psychological effects, and additive serotonergic toxicity is possible, although data are sparse.
What this interaction means in plain words
Desipramine and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Serotonergic 5-HT2A agonism from LSD combined with desipramine's monoamine reuptake inhibition may produce additive or altered serotonergic effects; the interaction is not well characterised.
What to do
Counsel patients to avoid recreational LSD while taking desipramine. If exposure occurs, monitor for agitation, hyperthermia, tachycardia and neuromuscular signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Lsd?
MediHelp rates the interaction as moderate. Desipramine and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. LSD acts as a serotonin receptor agonist, and tricyclic antidepressants such as desipramine may change the intensity of its effects. Combined use may produce unpredictable psychological effects, and additive serotonergic toxicity is possible, although data are sparse.
How serious is the interaction between Desipramine and Lsd?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid recreational LSD while taking desipramine. If exposure occurs, monitor for agitation, hyperthermia, tachycardia and neuromuscular signs of serotonin toxicity.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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