Drug interactions
Desipramine + Metoclopramide intranasal
Severity: Moderate
Desipramine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause extrapyramidal effects and, with tricyclics, may increase the risk of serotonin syndrome or neuroleptic malignant syndrome. Desipramine may also reduce the benefit of metoclopramide through anticholinergic effects.
What this interaction means in plain words
Desipramine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopaminergic and serotonergic effects, with opposing anticholinergic effects on gut motility.
What to do
Monitor for movement disorders, mental status changes and hyperthermia, and consider an alternative antiemetic if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Desipramine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause extrapyramidal effects and, with tricyclics, may increase the risk of serotonin syndrome or neuroleptic malignant syndrome. Desipramine may also reduce the benefit of metoclopramide through anticholinergic effects.
How serious is the interaction between Desipramine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for movement disorders, mental status changes and hyperthermia, and consider an alternative antiemetic if they occur.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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