Drug interactions
Desipramine + Motherwort
Severity: Minor
Desipramine and Motherwort: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Motherwort is traditionally used as a mild sedative, so it may add to the drowsiness caused by desipramine. Evidence is limited to traditional use and theoretical considerations.
What this interaction means in plain words
Desipramine and Motherwort have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive sedation; the mechanism of motherwort sedation is not well established.
What to do
Advise patients to watch for excess drowsiness and to avoid driving if affected. Stop the herb if sedation is troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Motherwort?
MediHelp rates the interaction as minor. Desipramine and Motherwort have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Motherwort is traditionally used as a mild sedative, so it may add to the drowsiness caused by desipramine. Evidence is limited to traditional use and theoretical considerations.
How serious is the interaction between Desipramine and Motherwort?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for excess drowsiness and to avoid driving if affected. Stop the herb if sedation is troublesome.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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