Drug interactions
Desipramine + Moxonidine
Severity: Moderate
Desipramine and Moxonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may reduce the antihypertensive effect of moxonidine, and the label advises against combining them. Both drugs can also cause sedation, and desipramine may blunt central alpha-2 mediated blood pressure lowering.
What this interaction means in plain words
Desipramine and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism of central sympatholytic action by tricyclic noradrenergic effects, with additive sedation.
What to do
Monitor blood pressure after starting or changing desipramine and adjust antihypertensive therapy if control is lost. Consider another antidepressant class if blood pressure stays uncontrolled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Moxonidine?
MediHelp rates the interaction as moderate. Desipramine and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants may reduce the antihypertensive effect of moxonidine, and the label advises against combining them. Both drugs can also cause sedation, and desipramine may blunt central alpha-2 mediated blood pressure lowering.
How serious is the interaction between Desipramine and Moxonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or changing desipramine and adjust antihypertensive therapy if control is lost. Consider another antidepressant class if blood pressure stays uncontrolled.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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