Drug interactions
Desipramine + Netupitant / palonosetron
Severity: Moderate
Desipramine and Netupitant / palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palonosetron is a 5-HT3 antagonist and serotonergic drug combinations carry a small risk of serotonin syndrome. Netupitant also inhibits CYP3A4 and may modestly raise desipramine exposure.
What this interaction means in plain words
Desipramine and Netupitant / palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effect, with CYP3A4 inhibition by netupitant.
What to do
Monitor for agitation, tremor, hyperthermia and other signs of serotonin toxicity after dosing, and for tricyclic adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Netupitant / palonosetron?
MediHelp rates the interaction as moderate. Desipramine and Netupitant / palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palonosetron is a 5-HT3 antagonist and serotonergic drug combinations carry a small risk of serotonin syndrome. Netupitant also inhibits CYP3A4 and may modestly raise desipramine exposure.
How serious is the interaction between Desipramine and Netupitant / palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia and other signs of serotonin toxicity after dosing, and for tricyclic adverse effects.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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