Drug interactions
Desipramine + Olodaterol inhaled
Severity: Moderate
Desipramine and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of long-acting beta2 agonists and may prolong the QTc interval. This can increase the risk of ventricular arrhythmias, although systemic exposure from inhaled olodaterol is low.
What this interaction means in plain words
Desipramine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and beta-adrenergic cardiovascular stimulation.
What to do
Use the approved olodaterol dose only and monitor for palpitations and arrhythmia. Check an ECG and potassium in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Desipramine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of long-acting beta2 agonists and may prolong the QTc interval. This can increase the risk of ventricular arrhythmias, although systemic exposure from inhaled olodaterol is low.
How serious is the interaction between Desipramine and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the approved olodaterol dose only and monitor for palpitations and arrhythmia. Check an ECG and potassium in patients with cardiac risk factors.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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