Drug interactions
Desipramine + Papaveretum
Severity: Moderate
Desipramine and Papaveretum: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum contains opium alkaloids including morphine, and combining it with desipramine can intensify sedation and psychomotor impairment. Respiratory depression and hypotension are possible, and tricyclics may also potentiate opioid effects.
What this interaction means in plain words
Desipramine and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression.
What to do
Start with lower opioid doses and titrate carefully while monitoring sedation and respiratory rate. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Papaveretum?
MediHelp rates the interaction as moderate. Desipramine and Papaveretum can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Papaveretum contains opium alkaloids including morphine, and combining it with desipramine can intensify sedation and psychomotor impairment. Respiratory depression and hypotension are possible, and tricyclics may also potentiate opioid effects.
How serious is the interaction between Desipramine and Papaveretum?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower opioid doses and titrate carefully while monitoring sedation and respiratory rate. Counsel patients to avoid driving and alcohol.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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