Drug interactions
Desipramine + Parecoxib
Severity: Minor
Desipramine and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is rapidly converted to valdecoxib, which is a weak CYP2D6 inhibitor and may modestly raise desipramine concentrations. The clinical effect is generally small but could increase tricyclic adverse effects such as anticholinergic symptoms and cardiac conduction changes.
What this interaction means in plain words
Desipramine and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP2D6-mediated desipramine metabolism by valdecoxib.
What to do
No routine dose change is needed; watch for tricyclic toxicity such as tachycardia, dry mouth or sedation. Consider checking a desipramine level if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Desipramine and Parecoxib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Parecoxib?
MediHelp rates the interaction as minor. Desipramine and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib is rapidly converted to valdecoxib, which is a weak CYP2D6 inhibitor and may modestly raise desipramine concentrations. The clinical effect is generally small but could increase tricyclic adverse effects such as anticholinergic symptoms and cardiac conduction changes.
How serious is the interaction between Desipramine and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for tricyclic toxicity such as tachycardia, dry mouth or sedation. Consider checking a desipramine level if symptoms appear.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
