Drug interactions
Desipramine + Pirbuterol
Severity: Moderate
Desipramine and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine, a strongly noradrenergic tricyclic, may exaggerate the cardiovascular effects of pirbuterol, including tachycardia, hypertension and arrhythmia.
What this interaction means in plain words
Desipramine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Desipramine potently inhibits noradrenaline reuptake, which can potentiate sympathomimetic effects.
What to do
Monitor heart rate, blood pressure and rhythm when the two are combined. Use the lowest effective pirbuterol dose and consider alternatives if cardiac effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Pirbuterol?
MediHelp rates the interaction as moderate. Desipramine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine, a strongly noradrenergic tricyclic, may exaggerate the cardiovascular effects of pirbuterol, including tachycardia, hypertension and arrhythmia.
How serious is the interaction between Desipramine and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and rhythm when the two are combined. Use the lowest effective pirbuterol dose and consider alternatives if cardiac effects appear.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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