Drug interactions
Desipramine + Propantheline
Severity: Moderate
Desipramine and Propantheline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are anticholinergic, so combined use can cause pronounced dry mouth, constipation, urinary retention, blurred vision and tachycardia. In older patients or those with glaucoma or prostatic enlargement, the effects may be significant, including ileus or confusion.
What this interaction means in plain words
Desipramine and Propantheline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic toxicity and reduce doses or select non-anticholinergic alternatives if symptoms emerge. Avoid in patients with narrow-angle glaucoma or urinary obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Propantheline?
MediHelp rates the interaction as moderate. Desipramine and Propantheline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are anticholinergic, so combined use can cause pronounced dry mouth, constipation, urinary retention, blurred vision and tachycardia. In older patients or those with glaucoma or prostatic enlargement, the effects may be significant, including ileus or confusion.
How serious is the interaction between Desipramine and Propantheline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and reduce doses or select non-anticholinergic alternatives if symptoms emerge. Avoid in patients with narrow-angle glaucoma or urinary obstruction.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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