Drug interactions
Desipramine + Remimazolam
Severity: Moderate
Desipramine and Remimazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam is a short-acting benzodiazepine and desipramine has sedative properties, so together they can deepen sedation. Excessive sedation and respiratory depression may occur, especially during procedural sedation.
What this interaction means in plain words
Desipramine and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation by remimazolam and sedative actions of desipramine.
What to do
Titrate remimazolam carefully, using lower doses if needed, and continuously monitor oxygen saturation, respiration and blood pressure through recovery. Ensure airway support is available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Remimazolam
Frequently asked questions
Can I take Desipramine with Remimazolam?
MediHelp rates the interaction as moderate. Desipramine and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Remimazolam is a short-acting benzodiazepine and desipramine has sedative properties, so together they can deepen sedation. Excessive sedation and respiratory depression may occur, especially during procedural sedation.
How serious is the interaction between Desipramine and Remimazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully, using lower doses if needed, and continuously monitor oxygen saturation, respiration and blood pressure through recovery. Ensure airway support is available.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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