Drug interactions
Desipramine + Romidepsin
Severity: Moderate
Desipramine and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin has been associated with ECG changes including QT prolongation, and desipramine can also prolong QT. Combined use may raise the risk of ventricular arrhythmia, particularly with electrolyte disturbance.
What this interaction means in plain words
Desipramine and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarisation leading to QT prolongation.
What to do
Check baseline ECG and correct potassium and magnesium before each romidepsin cycle. Monitor ECG during combined therapy and consider an alternative antidepressant if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Romidepsin?
MediHelp rates the interaction as moderate. Desipramine and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin has been associated with ECG changes including QT prolongation, and desipramine can also prolong QT. Combined use may raise the risk of ventricular arrhythmia, particularly with electrolyte disturbance.
How serious is the interaction between Desipramine and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium before each romidepsin cycle. Monitor ECG during combined therapy and consider an alternative antidepressant if QTc lengthens.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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