Drug interactions
Desipramine + Same
Severity: Moderate
Desipramine and Same: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) is a supplement with reported serotonergic activity, and cases of serotonin syndrome have been described with antidepressants. Combined use with desipramine may add to serotonergic effects, although the evidence is limited.
What this interaction means in plain words
Desipramine and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic and monoaminergic effects; the mechanism is not firmly established.
What to do
Avoid combining unless there is a clear reason, and counsel patients on symptoms of serotonin toxicity such as agitation, tremor, sweating and hyperreflexia. Stop SAMe if such symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Same?
MediHelp rates the interaction as moderate. Desipramine and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. S-adenosylmethionine (SAMe) is a supplement with reported serotonergic activity, and cases of serotonin syndrome have been described with antidepressants. Combined use with desipramine may add to serotonergic effects, although the evidence is limited.
How serious is the interaction between Desipramine and Same?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless there is a clear reason, and counsel patients on symptoms of serotonin toxicity such as agitation, tremor, sweating and hyperreflexia. Stop SAMe if such symptoms appear.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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