Drug interactions
Desipramine + Scullcap
Severity: Minor
Desipramine and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap is a herbal product with traditional sedative properties, so it may add to the sedation caused by desipramine. Evidence is limited and the effect is probably mild.
What this interaction means in plain words
Desipramine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depressant effects; mechanism not well established.
What to do
Advise patients to report excess drowsiness and avoid driving if sedated. Consider stopping the herbal product if sedation is troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Scullcap?
MediHelp rates the interaction as minor. Desipramine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap is a herbal product with traditional sedative properties, so it may add to the sedation caused by desipramine. Evidence is limited and the effect is probably mild.
How serious is the interaction between Desipramine and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report excess drowsiness and avoid driving if sedated. Consider stopping the herbal product if sedation is troublesome.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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